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Molecular Biosciences and Bioengineering (MBBE)

College of Tropical Agriculture and Human Resources

MBBE 304 Biotechnology: Science and Ethical Issues (3) Introduction to the concepts, goals, ethical issues and consequences of biotechnology using real-life case studies of cloning, DNA fingerprinting, gene therapy and genetical engineering. Pre: BIOL 171 or consent. (Cross-listed as BIOL 304)

MBBE 375 Essential Biochemistry (3) Introduction to basic concepts of cellular biochemistry and metabolic pathways as applied to nutritional, medicinal and environmental biochemistry. A-F only. Pre: CHEM 152 or CHEM 272 or BIOC 341, or consent.

MBBE 401 Molecular Biotechnology (3) General principles, applications, and recent advances of the rapidly growing science of biotechnology. Topics include impact of biotechnology on medicine, animal sciences, environment, agriculture, forensics, and economic and socio-ethical issues. Pre: C (not C-) or better in BIOL 275 or consent. (Cross-listed as BIOL 401) DB

MBBE 402 Principles of Biochemistry (4) Molecular basis of living processes in bacteria, plants and animals; emphasis on metabolism of carbohydrates, lipids, proteins and nucleic acids. Pre: C (not C-) or better in BIOL 275/275L, CHEM 272 and CHEM 273; or consent. (Cross-listed as BIOL 402 and PEPS 402) DB

MBBE 402L Principles of Biochemistry Lab (2) (1 Lec, 1 3-hr Lab) Principle techniques of biochemical laboratory. A-F only. Pre: 402 (or concurrent), BIOL 402 (or concurrent). DY

MBBE 405 Marine Functional Ecology and Biotechnology (3) Marine functional genomics, biodiversity of marine natural habitats, marine microbial communities and their ecological functions, interactions of marine microbes and their host, climate change and marine biodiversity, marine biotechnology. A-F only. Pre: OCN 201 or MICR 130, or consent. (Spring only) (Cross-listed as OCN 403)

MBBE 408 Molecular Cellular Biology II (3) Cell structure and function. Structure, chemistry, and functions of organelles and macromolecules. Pre: C (not C-) or better in BIOL 407; or consent. (Cross-listed as BIOL 408 and MCB 408) DB

MBBE 412 Environmental Biochemistry (3) Biochemical and chemical principles of occurrence, distribution, biotic and abiotic conversion, fate, and impact of synthetic and natural molecules in the environment. Important pollutants will be used as case studies to illustrate the principles. A-F only. Pre: CHEM 152 or CHEM 272, and CHEM 162 or CHEM 171; or consent. (Spring only) (Cross-listed as PEPS 412) DB

MBBE 461 Biotechnology for Teachers (3) Principles, methods, classical examples, recent development, benefits and concerns of modern biotechnology. Pre: BIOL 304 or equivalent.

MBBE 480 Integrative Genomics and Biotechnology (3) Integration of molecular genetics, virology, plant molecular biology, and bioinformatics. Gene silencing, functional genomics, and the development of expression systems for the production of heterologous proteins. A-F only. Pre: 401 and BIOL 275/275L; or consent. (Fall only) DB

MBBE 480L Integrative Genomics and Biotechnology Lab (3) Laboratory to accompany 480. A-F only. Pre: 401 and BIOL 275/275L; or consent. (Spring only) DY

MBBE 483 Introduction to Bioinformatics Topics for Biologists (3) Focuses on the use of computational tools and approaches to analyze the enormous amount of biological data (DNA, RNA, protein) available today. A-F only. Pre: BIOL 171 (or equivalent), or consent. (Once a year) (Cross-listed as BIOL 483)

MBBE 490 Lab Automation: Advanced Techniques in Plant Molecular Biology (3) Combined lab lecture on semi-automated systems used to analyze and manipulate nucleic acids and proteins. A-F only. Pre: 401 and BIOL 275/275L, or consent. (Once a year)

MBBE 491 Special Topics in MBBE (V) Study and discussion of special topics and problems in molecular biosciences and bioengineering. Pre: consent.

MBBE 499 Directed Research (V) Supervised individual instruction in laboratory research problems in biochemistry, molecular and cellular biology, genomics, and genetics. Repeatable 3 times or up to 16 credits. Limited to qualified undergraduate students. A-F only.

MBBE 601 Molecular Cell Biology (3) Provide fundamental concepts and dynamic characteristics of the molecules of the prokaryotic and eukaryotic cell, their biosynthesis and regulation, and the mechanisms that regulate cellular activities. A-F only. Pre: basic course in cell and molecular biology, or consent. (Fall only) (Cross-listed as MICR 601)

MBBE 607 Advanced Food Science I (3) Advanced topics in chemical and physical characteristics of foods as well as their role in human nutrition. Repeatable one time. A-F only. Pre: graduate student status with undergraduate courses in organic chemistry, microbiology, additional biological science, physics, and biochemistry. Basic knowledge of food science is expected; or consent. (Cross-listed as FSHN 607)

MBBE 610 Molecular Biosciences Seminar (1) Study and discussion of significant topics and problems in plant physiology, biochemistry, and molecular biology. Repeatable three times. A-F only.

MBBE 620 Plant Biochemistry (3) Comprehensive study of chemical constituents and biochemical processes unique to the plant kingdom with emphasis on selected aspects of current interest. A-F only. Pre: 402 or consent.

MBBE 621 Metabolic Engineering (4) Principles and methodologies of metabolic engineering. Concepts of metabolic networks. Establishment of metabolic flux analysis and metabolic control analysis. Systems biology framework for integration of mathematical modeling and global measurements at metabolite, protein and transcription levels. Pre: BIOL 275, MATH 311, and MICR 351; or consent.

MBBE 625 Biosensor Principles and Applications (3) Elaboration of common biochemical interactions used to quantify biological molecules, and the electrical technologies used to detect them. Discussion of the desirable properties of biosensors, miniaturization and applications related to medicine, agriculture, bioproduction and environment. Pre: consent. (Cross-listed as BE 625)

MBBE 650 DNA and Genetic Analysis (2) Combined lecture-lab for students interested in genetic analysis of humans, animals, and other species. Molecular techniques, such as PCR, DNA marker identifications, transgenics, expression analysis and functional genomics, are included. Open to nonmajors. Pre: graduate standing or consent. (Cross-listed as ANSC 650 and FSHN 650)

MBBE 651 Signal Transduction and Regulation of Gene Transcription (3) Lecture/discussion on molecular mechanisms involved in the transmission of regulatory signals from the cell surface to the nucleus. A-F only. Pre: CMB 621, and CMB 654 or equivalent; or consent. (Fall only)

MBBE 652 Molecular Plant–Fungal Interactions (3) Focuses on the actions of plant pathogenic fungi/oomycetes and their host responses at the molecular and cellular level. Current genetic and genomic approaches to study plant-fungal interactions will be discussed. Graduate standing only. Pre: consent. (Every 2 years) (Cross-listed as PEPS 652)

MBBE 680 Methods in Plant Molecular Biology (3) (1 Lec, 2 3-hr Lab) Advanced methodology and research strategies. Hands-on laboratory training in basic and current molecular procedures for plant research. Pre: one of BIOC 481 or BIOL 407.

MBBE 683 Advanced Bioinformatics Topics for Biologists (4) Teaches problem-solving with bioinformatic tools. Real-world problems will be provided and worked out, students encouraged to provide their own research problem where they require assistance. Graduate student must work on genomics research project requiring bioinformatic analysis, working knowledge of UNIX OS, Perl, Java or C. A-F only. Pre: ICS 471 and ICS 491 and ICS 691 (or equivalent), or consent. (Alt. years)

MBBE 687 Advanced Lab Techniques (1) (1 Lec, 2 3-hr Lab) Advanced laboratory techniques used in life science research. Pre: graduate standing or consent. (Cross-listed as ANSC 687 and FSHN 687)

MBBE 691 Advanced Special Topics in MBBE (V) Study and discussion of advanced special topics and problems in molecular biosciences and bioengineering. Pre: graduate standing or consent.

MBBE 699 Directed Research (V) Repeatable up to 64 credits.

MBBE 700 Thesis Research (V) CR/NC only.

MBBE 800 Dissertation Research (V) CR/NC only.